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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
70 Results for "
Trachycarpus fortunei (Hook.) H. Wendl.
" in MedChemExpress (MCE) Product Catalog:
Products (70)
70 Results for "Trachycarpus fortunei (Hook.) H. Wendl." in MCE Product Catalog:
6
Category:
Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids
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4
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1
1 Cited Publications
Cat. No.: HY-N0838
CAS No.: 24316-19-6
Synonyms: (-)-Cephalotaxine; ZINC19795976
Category:
Pyrrole Alkaloids Plants Cephalotaxaceae Cephalotaxus fortunei Hooker Infection Alkaloids Taxaceae Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
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1
1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
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Cat. No.: HY-N5037
CAS No.: 109008-27-7
Category:
Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf
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MS6105 is a PROTAC degrader targeting LDHA and LDHB, with DC50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research .
Cat. No.: HY-N0476
CAS No.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Category:
Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-161108
CAS No.: 2597167-34-3
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PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
Cat. No.: HY-N10925
CAS No.: 61955-76-8
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Cat. No.: HY-N4307
CAS No.: 72361-67-2
Category:
Infection Alkaloids Phenols Polyphenols Plants Lauraceae Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.
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Cat. No.: HY-N1072
CAS No.: 37239-47-7
Category:
Terpenoids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-162331
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STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
Cat. No.: HY-169481
CAS No.: 3027918-96-0
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AP-1 is a targeted ALK PROTAC degrader. AP-1 effectively degrades various ALK fusion/mutation forms, including degradation of NPM-ALK (DC50 = 4.6 nM) and EML4-ALK (DC50 = 357.6 nM), and exhibits a typical hook effect at high concentrations. AP-1 inhibits phosphorylation of downstream STAT3, downregulates gene expression in the JAK-STAT pathway, and kills ALK-positive tumor cells via activating the caspase-3-dependent apoptosis pathway. AP-1 shows cytotoxicity against a variety of cancer cells and possesses anti-tumor activity. AP-1 can be used in research related to non-small cell lung cancer, neuroblastoma, and anaplastic large cell lymphoma .
Cat. No.: HY-N6256
CAS No.: 108906-69-0
Category:
Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf
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Cat. No.: HY-32736R
CAS No.: 38647-11-9
Synonyms: NSC 165677 (Standard); PG 492 (Standard)
Cat. No.: HY-156401
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BRD9 Degrader-1 is a selective BRD9 PROTAC degrader with a DC50 of 108 nM. BRD9 Degrader-1 induces the formation of a ternary complex between BRD9 and VHL, with an EC50 of 17 nM, and shows no hook effect at high concentrations. BRD9 Degrader-1 can be used for the research of synovial sarcoma .
Cat. No.: HY-P991634
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Cat. No.: HY-RS06287
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HOOK1 Human Pre-designed siRNA Set A contains three designed siRNAs for HOOK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06288
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HOOK2 Human Pre-designed siRNA Set A contains three designed siRNAs for HOOK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
